Our laboratory is involved in the use of biological systems as models for the elaboration of new concepts at the interface between organic, supramolecular, macromolecular chemistry and biology. These concepts are subsequently used in the design of functional complex assemblies derived from nonbiological building blocks by following the biological principles structure determines functions.1-5 This lecture will discuss the elaboration of helical porous supramolecular and macromolecular structures as mimics of helical porous transmembrane proteins and their use in the reconstruction of the cell membrane and of its fundamental transport functions.6,7 Additional biological systems will be used to assemble complex assemblies that acts as molecular machines. The design of supramolecular systems that display the most primitive sign of intelligence such as memory effect will also be discussed.
(1) S. D. Hudson, H.-T. Jung, V. Percec, W.-D. Cho, G. Johansson, G. Ungar and V. S. K. Balagurusamy. Science 1997, 278, 449-452.
(2) V. Percec, C.-H. Ahn, G. Ungar, D. J. P. Yeardley, M. Moeller and S. S. Sheiko. Nature 1998, 391, 161-164.
(3) V. Percec, M. Glodde, T. K. Bera, Y. Miura, I. Shiyanovskaya, K. D. Singer, V. S. K. Balagurusamy, P. A. Heiney, I. Schnell, A. Rapp, H.-W. Spiess, S. D. Hudson, and H. Duan. Nature 2002, 419, 384-387
(4) G. Ungar, Y. Liu, X. Zeng, V. Percec and W.-D. Cho. Science 2003, 299, 1208-1211
(5) X. Zeng, G. Ungar, Y. Liu, V. Percec, A. Dulcey and J. K. Hobbs. Nature 2004, 428, 157-160.
(6) V. Percec, A. Dulcey, V. S. K. Balagurusamy, Y. Miura, J. Smidrkal, M. Peterca, S. Nummelin, U. Edlund, S. D. Hudson, P. A. Heiney, H. Duan, S. N. Magonov and S. A. Vinogradov. Nature 2004, 430, 764-768.
(7) V. Percec, A. E. Dulcey, M. Peterca, M. Ilies, S. Nummelin, M. J. Sienkowska and P. A. Heiney. Proc. Natl. Acad. Sci. USA 2006, 103, 2518-2523.
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