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Biocompatible and biodegradable pH responsive hydrogels have been studied extensively as controlled / targeted drug delivery system. pH responsive hydrogels of Chitosan and Acrylic acid were synthesized . Glutaraldehyde and N, N methylene bisacrylamide were used as cross linker for chitosan and acrylic acid respectively. The swelling characteristics of the interpenetrating network of chitosan and acrylic acid hydrogels were investigated at pH 7.4 and pH 3.0. On increasing bis concentration, the swelling decreased. FTIR spectra confirmed the formulation of polyelectrolyte complexes due to reaction between amino groups of chitosan and carboxyl groups of acrylic acids. The dry metronidazole was loaded into these hydrogels and release study was carried with bis concentration as variable at pH 1.2. |