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Future diagnostics will depend on fast, specific assays to allow personalized medical diagnostics. Increasing efforts in our group have therefore been put into the development of instrumental measurement- and functionalization schemes for cantilever-based sensors for the label-free detection of physical- and chemical phenomena of biological interactions. Cantilevers arrays offer an elegant approach where physiological ligand-receptor binding interactions occurring on the sensor generate nanomechanical signals like bending or a change in mass that is optically detected in-situ. This allows a comprehensive characterization of biological interactions: The measured mass gives information about the binding event whereas the measured surface stress (structural changes) gives insights in the effects of the ligand on the biological systems.
We report on new styles of combined measurements in the field of proteomics, genomics and present fast dynamic assessments of micro-organism growth on cantilever arrays.
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